Endocrine Abstracts

Background: SGLT-2 inhibitors (SGLT-2i) are used in treatment of type 2 diabetes mellitus (T2DM) through increasing urinary glucose secretion. Cases of euglycemic and hyperglycaemic diabetic ketoacidosis (DKA) have been reported in literature in patients using SGLT-2i. Increased glucose urinary excretion promoted by SGLT2i, decreases the production of insulin. In turn, lipolysis and ketone production increase predisposing the patient to developing DKA. It is hypothesised that ...

Introduction: Multiple Endocrine Neoplasms (MEN) are a group of rare hereditary tumours which have strong predisposition to endocrine organs. MEN1 is an autosomal-dominant inherited neoplasm with a broad genetic phenotype, characterised by synchronised or asynchronous triad neoplasms localised in the anterior pituitary, parathyroid and pancreas (Kamilaris and Stratakis, 2019; Li et al., 2022). Despite advances in the fields of diagnostic techniques and therapies, MEN1...